Rickets is a bone disorder that usually affects the smaller joints, especially the toes. It causes softening of the bones making them weak and porous. The most common cause of rickets is the deficiency of vitamin D. Hence, the primary line of treatment of rickets involves the use of vitamin D and calcium supplements. However, it has been observed that the immunological causes of rickets can also increase the risk of this condition by interfering with the metabolism of vitamin D.
Hence, it is advisable to detect the underlying immunological abnormalities for improving the outcomes of the treatment of rickets. Here is a brief discussion about how the immune system could contribute to the causes of rickets and hamper the recovery of patients.
Role of the immune system in worsening the pathogenesis and causes of rickets
Affects bone turnover
Bone turnover refers to the rate of formation of new bone cells in comparison with the rate of loss of old and damaged bone cells. If the rate of bone loss exceeds the rate of bone formation, it can result in reduced bone mineral density. It can make the bones weak and porous thereby triggering the development of rickets in children and osteoporosis in adults.
The risk of rickets is higher in children who have vitamin D deficiency along with immunological dysfunctions. The improper functions of the immune system may affect the ability of the body to form new bone cells. It may also hamper the absorption of calcium and vitamin D from the intestine. As a result, the bones are deprived of these essential nutrients thus worsening the causes of rickets.
Increases the risk of complications
Clinical research aimed at assessing the effect of vitamin D3 on immune system functions and bone health has revealed the immunological causes of rickets.
These studies have indicated that children who have a vitamin D deficiency are more prone to develop infective diseases. The deficiency of vitamin D can affect the activities of the immune cells and cause a reduction in the production of natural killer cells and B cells. The results of this study have shown that these abnormalities linked to the immune system can increase the risk of infections in patients with nutritional rickets.
This is why; the treatment of rickets should be aimed at ensuring the body receives an adequate supply of vitamin D to restore healthy immune system functions. Patients can also use supplements to support immunity in order to improve the ability of immune cells to fight infections. This could help to overcome long-term vitamin D deficiency and support the recovery of patients with rickets.
Hampers bone resorption
The immune system can regulate the processes involved in bone resorption. The chemical compounds released by the immune cells called interleukins can act as peptide stimulators and regulate the bone resorption processes.
These compounds also produce a direct effect on the osteoclasts that cause the breakdown of the bone tissues as well as the bone-forming cells called osteoblasts.
The abnormal functioning of immune cells might reduce the ability of the interleukins to control the activities of the osteoclasts and osteoblasts. This may lead to a faster breakdown of the bone cells without the formation of an adequate level of new cells.
These abnormal changes linked to the immune system may contribute to the causes of rickets in children who already have a deficiency of vitamin D. It could make their bones spongy and weaker resulting in the bowing of the long bones of the legs.
Hence, it is important to address the immunological causes of rickets to prevent the complications of this condition.
The risk of rickets could be prevented by ensuring the body receives an adequate supply of vitamin D and calcium. However, the immunological causes of rickets may hamper the recovery of patients. Hence, it is advisable to combine the use of vitamin D and calcium supplements with BioPro-Plus for correcting the immune system functions.
BioPro-Plus is an immunity-modulating supplement that helps to enhance the ability of the immune cells to attack pathogens and prevent infections. It also aids in promoting the bone formation processes thereby increasing bone strength.
Regular use of BioPro-Plus along with vitamin D and calcium supplements is expected to improve bone mineral density and protect the bones against the common causes of rickets including immunological dysfunctions.