Bisphosphonates are the groups of drugs commonly used for the treatment of osteoporosis. Osteoporosis is a bone disorder that occurs due to the loss of bone mineral density usually as a result of aging. Osteoporosis causes bones to become weaker. It also makes bones more fragile, thinner, and prone to breaking. The use of Bisphosphonates is often recommended by doctors for the management of this condition. However, it is important to be aware of the pros and cons of Bisphosphonates in order to maximize the benefits and avoid the side effects. 

Here is a brief discussion about the pros and cons of bisphosphonates for the management of osteoporosis. 

What are the Pros and Cons of Bisphosphonates? 

Reduces Osteoporosis Risk 

Bisphosphonates can reduce the risk of osteoporosis and fractures substantially. It is estimated that nearly one in two women and one in four men above 50 years of age are likely to break a bone due to this condition. The regular use of Bisphosphonates as recommended by a physician could lower the risk of these complications. 

However, this medication is specifically suitable for those who have osteoporosis with a T-score lower than -2.5 or those who have had a fracture.  

Men and women, who have not had a fracture but have a low bone density with a T-score between -1.0 and -2.5, can also use this medication to avoid complications like a fracture. However, the evidence of the benefits of using bisphosphonates in such cases is not very strong. 

Hence, being aware of the pros and cons of Bisphosphonates and the specific indications for their use is essential for patients so that they can make the right decisions. It can help them develop a long-term treatment plan with their doctor based on their bone density and other health conditions that could be contributing to the deterioration in the bone mineral density. 

The Effect on Bone-Thinning Processes 

osteoporosisBisphosphonates work by slowing down the breakdown of the bone tissues and inhibiting the loss of calcium. Research studies have proven that these drugs can also help to prevent fractures and the bone-thinning processes. 

However, some patients may develop a jawbone problem called jaw necrosis, especially if they are using a very high dose of bisphosphonates. Recent research has also shown that the benefits of bisphosphonates tend to max out after about five years following which patients may not see any added benefits if they continue using the medication.

Patients should be aware of these pros and cons of bisphosphonates and exercise caution while using this drug so that they can derive the benefits such as preventing fractures while avoiding adverse effects like jaw necrosis. 

This side effect of bisphosphonates is linked to the impact of this medication on the immune system. Research studies have revealed that bisphosphonate exposure would lead to impaired neutrophil chemotaxis, reduced circulating neutrophil count, and neutrophil NADPH oxidase activity. This suggests that bisphosphonates may depress the activities of the innate immune system for a prolonged duration, possibly contributing to the development of jaw necrosis.

Pros and Cons of Bisphosphonates 

Potential Benefits of bisphosphonates

  • Improves bone mineral density
  • Reduces loss of calcium from the bone tissues
  • Prevents the risk of fractures
  • Slows down bone thinning processes

Potential Cons of bisphosphonates

  • Jaw necrosis 
  • Atypical femur fractures
  • Heartburn or gastric discomfort 
  • Affect on innate immune system 

Osteoporosis can be prevented by the timely detection of the loss of bone mineral density and taking treatment to slow down the decline in the bone density by using medications like Bisphosphonates. Other than Bisphosphonates, patients also need to focus on improving their nutrition, insuring they have adequate Vitamin D, Vitamin C and Calcium intake. They should also make efforts to improve the functions of their immune system to slow down degenerative changes and inflammation in the bones. 

Immunity-boosting supplements like BioPro-Plus can provide valuable support to patients at risk of osteoporosis. The regular use of BioPro-Plus is expected to help reduce the impact of bisphosphonates on the innate immune system. It could strengthen immunity and help protect the bones against degenerative and inflammatory changes. Awareness about the pros and cons of bisphosphonates, the ways to avoid the adverse effects of these drugs and understanding natural interventions to use instead are the keys to slowing down the pathogenesis of osteoporosis and reducing the risk of fractures.


  • https://www.nof.org/news/new-wall-street-journal-article-on-the-benefits-of-bisphosphonates-outweighing-the-risks-for-many-patients/