Inflammation forms the basis of the development of most disease. It is the body’s attempt to protect itself against diseases with the aim to remove any harmful stimuli such as damaged cells, infective pathogens, and irritants. The common causes of Inflammation include exposure of the body to harmful pathogens or irritants the response to which is regulated by the immune system.
Inflammation is often evident as a localized physical change in an organ or tissues of the body and is characterized by symptoms such as redness, heat, swelling, and pain. The acute inflammatory changes occurring in the body last for a period of a few hours to days and usually resolve on its own or with minor treatment.
However, chronic inflammation is characterized by long-term inflammatory changes in the body, which ultimately lead to considerable damage to healthy tissue. Chronic inflammation is often linked to abnormalities of the immune system and plays a role in the pathogenesis of many diseases including diabetes, cancer, Alzheimer’s disease, depression, arthritis, and heart disease. Here is a brief discussion about the role of the immune system in triggering the causes of inflammation.
How does the immune system trigger the causes of inflammation and disease development?
Effects neuroimmune communication network
Several disorders that are linked to inflammation occur due to the dysregulation of the neuroimmune communication network. For example; research studies have indicated that major depression occurring during pregnancy arises from a complex, multifactorial etiology.
Microglia receptors have been found to play a role in triggering the causes of inflammation by initiating a stress-induced response in pregnant women. The response is mediated through the activation of the inflammasome, which later leads to the synthesis of inflammatory cytokines by the immune system. This may also affect serotonin metabolism, and reduce the neurotransmitter availability while causing hypothalamic-pituitary-adrenal axis hyperactivity.
These changes have been associated with the dysregulation of the neuroimmune communication network in pregnant women. It is suggested that modifying the response of the immune system would help to correct the neuroimmune communication network and control the release of inflammatory substances like cytokines thereby reducing the symptoms of depression.
Promotes neuroinflammatory signaling
Abnormalities linked to the neuroinflammatory signaling processes that are regulated by the immune system are known to trigger the causes of inflammation. Research studies have shown that the pathogenesis and progression of Alzheimer’s disease is linked to the inflammatory changes in the brain and nervous system caused due to the dysfunctions of the immune system.
Glia-dependent neuroinflammatory mechanisms, which are regulated by the immune system are found to be dysfunctional in these patients. Also, the astrocytes and microglia are also the glial cell forms that respond to the disease stressors through the reaction of the innate immune system by initiating the production of inflammatory mediators.
The findings of this research point to the involvement of the immune system in contributing to the causes of inflammation in the development of conditions like Alzheimer’s disease. In addition, the population of peripheral myeloid cells and perivascular macrophages that have the ability to enter the affected brain tissues also participate in the neuroinflammatory signaling triggered by the abnormal immune system response. Hence, patients with Alzheimer’s disease are advised to take steps to correct their immune system functions to prevent disease development.
Innate immunity is commonly linked to inflammatory changes occurring in the body. The faulty response of the innate immune system can trigger the causes of inflammation. It has been found that regulatory mechanism derived from microorganisms and host can alter the inflammatory responses through different signaling pathways in varying cell types. This can lead to inflammatory changes in healthy tissue thereby leading to the development of disease.
Insights into the mechanisms regulated by the innate immune system are believed to lead to an improved understanding of the pathogenesis of several diseases and help form effective therapeutic strategies.
The results of these research studies indicate that immune system abnormalities can trigger the development and causes of inflammation in the body. The use of supplements that can help regulate the functions of the immune system such as BioPro-Plus is highly recommended to help inhibit these abnormal changes. Regular use of BioPro-Plus may aid in controlling the causes of inflammation in the body and reduce the risk of many common diseases.